Original Research Articles

  1. Conditional control of universal CAR T cells by cleavable OFF-switch adaptors. Kvorjak M, Ruffo E, Tivon Y, So V, Parikh A, Deiters A, Lohmueller J. ACS Synth Biol. 2023 Oct 4. doi: 10.1021/acssynbio.3c00320. PMID: 37791909 Link

  2. Post-translational covalent assembly of CAR and synNotch receptors for programmable antigen targeting. Ruffo E, Butchy AA, Tivon Y, So V, Kvorjak M, Parikh A, Adams EL, Miskov-Zivanov N, Finn OJ, Deiters A, Lohmueller J. Nat Commun. 2023 May 9;14(1):2463. doi: 10.1038/s41467-023-37863-5.PMID: 37160880. Link

Collaborative work

  1. Preventative Cancer Vaccine-Elicited Human Anti-MUC1 Antibodies Have Multiple Effector Functions. ML McKeague, J Lohmueller, MT Dracz, N Saadallah, ED Ricci, DM Beckwith, R Ayyalasomayajula, M Cudic, OJ Finn. Antibodies. 2024, 13(4), 85; doi: 10.3390/antib13040085. PMID: 39449327. Link

  2. CAR T cell infiltration and cytotoxic killing within the core of 3D breast cancer spheroids under the control of antigen sensing in microwell arrays. Cho Y, Laird MS, Bishop T, Li R, Jazwinska DE, Ruffo E, Lohmueller J, Zervantonakis IK.APL Bioeng. 2024 Jul 23;8(3):036105. doi: 10.1063/5.0207941. eCollection 2024 Sep.PMID: 39049849. Link

  3. Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors. Lontos K, Wang Y, Joshi SK, Frisch AT, Watson MJ, Kumar A, Menk AV, Wang Y, Cumberland R, Lohmueller J, Carrizosa E, Boyerinas B, Delgoffe GM. J Immunother Cancer. 2023 Mar;11(3):e006522. doi: 10.1136/jitc-2022-006522. PMID: 36914208. Link

  4. Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology. Lontos K, Wang Y, Mason Colbert M, Kumar A, Joshi S, Philbin M, Wang Y, Frisch A, Lohmueller J, Rivadeneira DB, Delgoffe GM. Oncoimmunology. 2022 Oct 18;11(1):2131229. PMID: 36275862. Link

  5. The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse. Kataoka S, Manandhar P, Lee J, Workman CJ, Banerjee H, Szymczak-Workman AL, Kvorjak M, Lohmueller J, Kane LP. Sci Signal. 2021 Jun 15;14(687), PMID: 34131021. Link

Jason’s previous papers

  1. Abnormally glycosylated MUC1 establishes a positive feedback circuit of inflammatory cytokines, mediated by NF-kB p65 and EzH2, in colitis-associated cancer. Cascio S, Faylo JL, Sciurba JC, Xue J, Ranganathan S, Lohmueller J, Beatty PL, Finn OJ. OncoTarget.2017 Oct 27;8(62):105284-105298. PubMed PMID: 29285251. Link

  2. Current modalities in cancer immunotherapy: immunomodulatory antibodies, CARs, and vaccines. Lohmueller J, Finn OJ. Review. Pharmacology & Therapeutics. 2017 Oct;178:31-47. PMID: 28322974, PMCID: PMC5600680. Link

  3. mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting. Lohmueller J, Ham JD, Kvorjak M, Finn OJ. OncoImmunology. 2017 Oct 26;7(1):e1368604. PubMed PMID: 29296519. Link

  4. Antibodies elicited by the first non-viral prophylactic cancer vaccine show tumor-specificity and immunotherapeutic potential. Lohmueller J, Sato S, Popova L, Chu IM, Tucker MA, Barberena R, Innocenti GM, Cudic M, Ham JD, Cheung WC, Polakiewicz RD, Finn OJ. Sci Rep. 2016 Aug 22;6:31740. PubMed PMID: 27545199. Link

  5. Synthetic biology in mammalian cells: Next generation genetic research tools and therapeutics. Lienert F, Lohmueller J, Garg A, Silver PA. Nature Reviews Molecular Cell Biology. 2014 Feb;15(2):95-107. PubMed PMID: 24434884. Link

  6. Protein scaffold-activated protein trans-splicing in mammalian cells. Selgrade DF*, Lohmueller J*, Lienert F, Silver PA. J Am Chem Soc. 2013 May 22;135(20):7713-9. PubMed PMID: 23621664 *Contributed equally Link

  7. Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, Tan L, Yang Y, Li S, Tang K, Chen H, Powell A, Itan Y, Fuller D, Lohmueller J, Mao J, Schachar A, Paymer M, Hostetter E, Byrne E, Burnett M, McMahon AP, Thomas MG, Lieberman DE, Jin L, Tabin CJ, Morgan BA, Sabeti PC. Cell. 2013 Feb 14;152(4):691-702. PubMed PMID: 23415220. Link

  8. Engineering synthetic TAL effectors with orthogonal target sites. Garg A*, Lohmueller J*, Silver PA, Armel TZ. Nucleic Acids Res. 2012 Aug;40(15):7584-95. PubMed PMID: 22581776  *Contributed equally Link

  9. A tunable zinc finger-based framework for Boolean logic computation in mammalian cells. Lohmueller J, Armel TZ, Silver PA. Nucleic Acids Res. 2012 Jun;40(11):5180-7. PubMed PMID: 22323524. Link

  10. MicroRNA circuits for transcriptional logic. Leisner M, Bleris L, Lohmueller J, Xie Z, Benenson Y. Methods Mol Biol. 2012;813:169-86. PubMed PMID: 22083742. Link

  11. Rationally designed logic integration of regulatory signals in mammalian cells. Leisner M, Bleris L, Lohmueller J, Xie Z, Benenson Y. Nature Nanotechnology. 2010 Sep;5(9):666-70. PubMed PMID: 20622866. Link

  12. Genome-wide detection and characterization of positive selection in human populations. Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF, Lander ES, International HapMap Consortium. Nature. 2007 Oct 18;449(7164):913-8. PubMed PMID: 17943131. Link

  13. Positive natural selection in the human lineage. Sabeti PC, Schaffner SF, Fry B, Lohmueller J, Varilly P, Shamovsky O, Palma A, Mikkelsen TS, Altshuler D, Lander ES. Science. 2006 Jun 16;312(5780):1614-20. PubMed PMID: 16778047. Link